Parkinson’s disease is a progressive nervous system disorder that affects movement. Symptoms start slowly, sometimes beginning with a hardly noticeable tremor in just 1 hand. Tremors are typical, but the disease also commonly causes slowing or stiffness of movement.
In the early stages of Parkinson’s disease, your face might reveal little if any expression. Your arms might not fold when you walk. Your speech may become tender or slurred.
Though Parkinson’s disease can’t be cured, medications might significantly improve your symptoms. Occasionally, your physician may suggest surgery to regulate certain areas of your brain and improve your symptoms.
Parkinson’s disease signs and symptoms may be different for everybody. Early signs can be mild and go undetected. Symptoms often begin on one side of the body and usually remain worse on that side, even after symptoms begin to affect either side.
Parkinson’s signs and symptoms may include:
A tremor, or shaking, usually begins in a limb, frequently your hand or hands. You will a rub on your thumb and forefinger back-and-forth, known as a pill-rolling tremor. Your hands may tremor when it is at rest.
Slowed movement (bradykinesia). Over time, Parkinson’s disease may slow your movement, making simple tasks difficult and time-consuming. Your steps may become shorter when you walk. It could be difficult to get out of a chair. You’ll drag your feet as you try to walk. Muscle stiffness may happen at any part of your body. The stiff muscles can be painful and restrict your range of movement.
Impaired posture and balance. Your posture might become stooped, or you may have balance problems because of Parkinson’s disease.
Reduction of automatic motions. You might have a diminished ability to execute unconscious movements, including blinking, smiling or swinging your arms when you walk.
Speech changes. You may talk softly, quickly, slur or hesitate before speaking. Your speech may be more of a monotone rather than with the usual inflections.
Writing changes. It might become difficult to compose, and your writing might appear modest.
In Parkinson’s disease, specific nerve cells (neurons) in the mind slowly break down or perish. A number of the indicators are because of a lack of neurons which make a chemical messenger in your brain called dopamine. When dopamine levels fall, it triggers abnormal brain activity, resulting in symptoms of Parkinson’s disease.
Scientists have identified certain genetic mutations which may cause Parkinson’s disease. However, these are rare except in rare instances with lots of family members impacted by Parkinson’s disease.
But, certain gene variations seem to raise the risk of Parkinson’s disease but using a rather modest risk of Parkinson’s disease for every one of those genetic markers.
Safety triggers. Exposure to certain toxins or environmental factors might increase the possibility of after Parkinson’s disease, but the danger is comparatively small.
Scientists also have noted that lots of changes occur in the brains of individuals with Parkinson’s disease, though it is not clear why those changes happen. These modifications include:
These are known as Lewy bodies, and researchers consider these Lewy bodies have a significant clue to the origin of Parkinson’s disease.
Alpha-synuclein is located inside Lewy bodies. Though many materials are observed within Lewy bodies, scientists also consider a significant one is the common and natural protein known as alpha-synuclein (a-synuclein). It is located in most Lewy bodies at a clumped type that cells can not break down. This is now a significant attention among Parkinson’s disease investigators.
Since CBD and THC are compounds that occur naturally in a plant, they were by definition not made to fight any of the symptoms of PD. It is unreasonable therefore to expect that they’ll be a way to all that ails a person with Parkinson’s. More research needs to be performed, but according to what is known about the biology of cannabis, one could hypothesize that THC and/or CBD can be helpful for facets of PD such as tremor, stiffness, insomnia, dystonia, pain, dyskinesias or weight loss.
.Which of these specific symptoms are helped?
.What ratios of THC and CBD work for a particular symptom?
Because the politics and history of marijuana trigger such powerful emotions, it is clear that the people has started to consider THC and CBD as distinctive materials with their particular rules. However they shouldn’t be viewed this way. They are chemicals found in plants which have effects on the human body and brain and might help people cope with some difficult medical symptoms. And if they’re used by humans to cope with a health symptom, then they are medications. To that end, we need to cure THC and CBD since the drugs they are and subject them to the same standards we do any drugs. Clinical trials can help us understand what signs they treat and what doses are needed. A major limitation to performing clinical trials using medical marijuana is the federal government continues to consider marijuana an illegal substance and won’t fund research involving marijuana. There are numerous efforts to try to alter this, together with the expectation of opening up medical marijuana to further research.
An individual must also consider that just like any medication, medical marijuana can interact with other prescription drugs like the ones that lead to sleepiness or thin blood. Additionally, medical marijuana may have side effects. And like any medication, the side effects will change depending upon the person taking it. Elderly patients tend to be more vulnerable to unwanted effects, for example. Some side effects which may occur include sleepiness, confusion, difficulty concentrating, apathy, mood fluctuations and gait imbalance. Therefore, before even considering medical marijuana, especially in the elderly, patients will need to discuss how marijuana interacts with their other drugs and weigh all of the risks and benefits with their physician.
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